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Tramadol is a centrally-acting oral pain medication.  It has been approved by the U.S. food and Drug Administration (FDA) and is a controlled substance under the controlled substance act (CSA) for the treatment of chronic pain in the adult population where other treatments do not yield desired results. Tramadol pain pills are very effective in dealing with the severity of pain. This drug works at the opioid pain receptor and also slows down the uptake of neurotransmitters – serotonin and norepinephrine which may add to the pain relief effects.